Coefficient of Inbreeding Formula:
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The Coefficient of Inbreeding (COI) measures the probability that two alleles at any locus in an individual are identical by descent from a common ancestor. It quantifies the degree of inbreeding in a pedigree.
The calculator uses the standard COI formula:
Where:
Explanation: The equation calculates the probability that two alleles from a common ancestor will be identical in the offspring.
Details: COI is crucial in animal breeding, conservation biology, and human genetics to assess inbreeding depression risks and genetic diversity.
Tips: Enter the number of generations for each parent's path to the common ancestor, the ancestor's inbreeding coefficient (0 if unknown), and the number of distinct common ancestral paths.
Q1: What does a COI of 0 mean?
A: A COI of 0 indicates no inbreeding - the parents share no common ancestors.
Q2: What is considered a high COI?
A: Values above 0.0625 (first cousins) are generally concerning, with higher values indicating greater inbreeding.
Q3: How does COI relate to genetic disorders?
A: Higher COI increases the probability of homozygous recessive deleterious alleles being expressed.
Q4: Can COI be negative?
A: No, COI ranges from 0 (no inbreeding) to 1 (complete inbreeding).
Q5: How accurate is this calculator for complex pedigrees?
A: For complex pedigrees with multiple common ancestors, specialized software may be needed for complete accuracy.