1. What is the Coefficient of Inbreeding?

The Coefficient of Inbreeding (COI) measures the probability that two alleles at any locus in an individual are identical by descent. It quantifies the genetic similarity between an individual's parents, expressed as a value between 0 and 1.

2. How Does the Calculator Work?

The calculator uses the Kennel Club COI formula:

Where:

• \( n \) — Number of generations separating the parents through their common ancestor
• \( F_a \) — Inbreeding coefficient of the common ancestor
• The sum is taken over all common ancestors in the pedigree

Explanation: The equation accounts for all possible paths through which genes could be identical by descent from common ancestors.

3. Importance of COI Calculation

Details: COI helps breeders manage genetic diversity, reduce risk of inherited disorders, and maintain breed health while preserving desirable traits.

4. Using the Calculator

Tips: Enter the number of generations back to common ancestors, count of common ancestors, and their inbreeding coefficients. Typical values range from 0 (unrelated) to 0.25 (sibling mating).

5. Frequently Asked Questions (FAQ)

Q1: What is a "safe" COI value?
A: Generally, COI below 6.25% is considered low risk, while above 12.5% may increase health concerns.

Q2: How many generations should be considered?
A: For accuracy, at least 5 generations should be included in pedigree analysis.

Q3: Does COI predict specific genetic disorders?
A: No, it only measures overall relatedness. Specific genetic testing is needed for disorder risk assessment.

Q4: How does COI relate to breed conservation?
A: Responsible breeders balance COI to maintain genetic diversity while preserving breed characteristics.

Q5: Can COI be reduced in a breed?
A: Yes, through careful outcrossing programs and strategic breeding with genetically diverse individuals.